ELECTROPHYSIOLOGY



If a microelectrode is introduced into a single myocardial cell, an action potential (Fig. 1-9) can be recorded by measuring the potential difference between the inside and the outside of the cell (in­side negative). The resting membrane potential of a normal Purkinje cell is approximately - 90 mil­livolts (mv) with respect to the outside of the cell. When the membrane potential is depolarized to a certain threshold level, an action potential occurs with a rapid upstroke (phase 0); a return toward zero from the initial overshoot or early rapid re­polarization (phase 1); a plateau (phase 2); final rapid repolarization (phase 3); and resting mem­brane potential and ” diastolic depolarization (phase 4). The normal resting potential is main­tained by the active (i.e., energy-requiring) exclu­sion of sodium and the accumulation of potas­sium inside the cell. Phase 0 or rapid depolarization is due chiefly to the opening of the sarcolemmal channels to sodium entrance in atrial and ventricular muscle and cells in the His-Purkinje system. Calcium is important in the maintenance of the action potential plateau of fast Action potentials recorded from different tissues in the heart remounted with a His bundle re­cording and scalar ECG from a patient to illustrate the timing during a single cardiac cycle. SN = Sinus nodal potential; A = atrial muscle potential; AVN = atrio­ventricular nodal potential; PF = Purkinje fiber poten­tial; V = ventricular muscle potential; HB = His bundle recording; II = lead II. The A-H interval measured in the His bundle recording approximates AV nodal con­duction time, and the H-V interval approximates His-Purkinje system conduction time.
sodium channel—dependent cells and in the gen­eration of the action potential upstroke in slow calcium channel—dependent cells such as the sinus and AV nodes. Phase 3 is mediated chiefly by an outward potassium current, and the mem­brane returns to its negative resting potential dur­ing electrical diastole. Automaticity is a property of some cardiac tissues to undergo gradual phase 4 depolarization spontaneously until threshold potential is reached and the cell initiates an action potential that is propagated from one cell to another. Nor­mal automaticity is present in sinus nodal tissue, some atrial and junctional tissues, the bundle branches, and Purkinje fibers. The sinus node dis­charges more rapidly than the other cells and is the normal pacemaker of the heart. Conduction is the propagation of a cardiac impulse and is most closely influenced by the amplitude and upstroke velocity of phase 0 of the action potential. Re­fractoriness is a property of cardiac tissue during which a stimulus occurring soon after a previous action potential fails to elicit another normal ac­tion potential; it is most closely related to the du­ration of phase 3 of the cardiac action potential in most tissues.
The genesis of the normal electrocardiogram is from electrical activity recorded by skin elec­trodes that is the sum of all the cardiaC action po­tentials of its component cells. The P wave rep­resents atrial depolarization. The PR interval is a measure of the time necessary to travel from the sinus node through the atrium, AV node, and His-Purkinje system to activate ventricular myocar­dial cells. The QRS complex represents the sum of all ventricular muscle cell depolarizations (phase 0), the ST segment represents the plateau phase, and the T wave represents the rapid re­polarization (phase 3) of the heart as a whole.
Although the autonomic nervous system may affect atrial and ventricular tissue to a small ex­tent, the most prominent autonomic effects are ob­served on the sinus and the AV nodes. Sym­pathetic stimulation increases the rate of automaticity and increases conduction velocity, whereas parasympathetic (vagal) activation does the opposite. Baroreceptors in the carotid sinus, located at the bifurcation of the internal and ex­ternal carotid arteries, activate the vagus nerve when blood pressure increases and reflexively de­crease heart rate and AV nodal conduction veloc­ity.





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